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The affect of beta blockers on adrenaline and cortisol levels.

Polymyalgia Rheumatica (PMR) | Last Active: Nov 7 10:00pm | Replies (14)
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@art43

After seeing “megzies” post this AM, I queried my cardiologist on the topic during a scheduled appointment.
My PMR has been in remission for about 10 months, I am down to 2.0 prednisone, decreasing 0.5 per month, and I have been on metoprolol ER 25 for about 18 years following a major MI and bypass. My BP today was 124.
Her feeling was that on my low metoprolol dose, there would be no or negligible effect on cortisol production or availability as I continue to taper.

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Replies to "After seeing “megzies” post this AM, I queried my cardiologist on the topic during a scheduled..."
megz | @megz | Nov 4 4:20pm

That consult with your cardiologist was quick. I only posted this less than a day ago.

I'm also currently on 25mg of metoprolol, having reduced last year down from 8yrs on 50mg following a heart attack. My BP yesterday was 116/78. I see there are new articles coming out this year calling metoprolol an "older" blood pressure medication which should be reviewed for some people as it affects things other than what's being treated. It also reduces melatonin production, so I take a small dose of melatonin each day to help with sleep, and renin production in the kidneys which affects salt/potassium balance, the same as prednisone does.

Good to hear that you're able to reduce prednisone to 2mg so far while taking 25mg of metoprolol. That gives me hope.

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