@loh, I understand your fears as I felt the same way prior to taking Tymlos (rarely took pain meds like Tylenol, Motrin, etc). I resisted taking any osteo meds for over 5 years until a friend helped me understand that my current choices would greatly impact my future health (duh). I then took Fosamax for two years with little change in bone density. A spontaneous fracture in my toe allowed my endocrinologist to fast track me to a bone building drug and I started with Tymlos. I ramped up on Tymlos over the course of a week and have had moderate pain in my legs throughout the past year but recently had a DEXA scan after one year on Tymlos and saw significantly improved numbers (from -3 to -2, for example). We have to take care of our future selves. Best of luck to you.