i am taking a supplement with the synolytic fisetin, also CoQ10, zinc, and ashwaganda as well as a pine extract supplement. That and fasting 16-18 hrs a few times a week. Something in this regime has helped. Besides the brain fog, i have erratic bp, (previously normotensive) mostly high but sometimes, extremely low. My bp meds were changed and i seem to have better control of the highs on amlodipine, a beta blocker, and losartan. Weaning losartan. This has helped as well.
I did read some research on nattokinase, but i had some bleeding/bruising issues on half a dose of natto, so had to stop that. Perhaps if you can afford a Functional Medicine person that might be helpful. I finally decided i was worth the out of pocket (cough cough $$) and i haven't regretted that decision.