Yes, I was on 75 mcg patches for about 9 months for severe and chronic migraines that didn’t respond to anything else. The Fentanyl patches were God sent. However, long term I think it deadens everything and made my depression worse. Finally got help through Botox Injections and methadone for a few years. Finally I no longer need the methadone because the Botox injections every 3 months seems to do really well although I’ve had some breakthrough headaches recently due to the stress of having to move 4 times in 3 months.