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New type of test for PSA: Prostate Screening EpiSwitch (PSE) test
Prostate Cancer | Last Active: Nov 3 3:50pm | Replies (6)Comment receiving replies
Actually @northoftheborder The literature reports a few cases of prostate cancer progressing while PSA is still low-ish (e.g. < 2.0),
I’ve seen a couple of articles that have warned there can be progression even though the PSA is very low.
Here is one of them from the arches study
https://dailynews.ascopubs.org/do/arches-analysis-underscores-importance-regular-imaging-detect-progression-patients
This really worries me since a PSMA pet test isn’t gonna work well if you’re PSA is < .1. But there can be radiographic progression which can be seen in the CT scans and bone scans. That’s why I get those scans yearly even though my PSA is undetectable.
They’re also the 10% of people that don’t produce PSMA so the PSMA Pet test doesn’t work for them. And then there’s those with neuroendocrine prostate cancer that can’t be seen by the PSMA pet test either. PSA can be undetectable for these groups, but progression is occurring.
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I think we wrote the same thing. 🙂
Me: "The literature reports a few cases of prostate cancer progressing while PSA is still low-ish (e.g. < 2.0), but personally I haven't yet read of progression when PSA is < 0.01 on the ultrasensitive test."
You: "Actually @northoftheborder The literature reports a few cases of prostate cancer progressing while PSA is still low-ish (e.g. < 2.0), "
Have you read of any cases of progression with PSA < 0.01? I haven't yet, but I'm keeping my eyes open.
The article you linked is interested: it mentions that the -lutamides can suppress PSA even in cases when cancer might be progressing, but it mentions only "quite low" and "nadir" vaguely, not fully undetectable PSA specifically. It would be interesting to know if any of those cases involved undetectable on the uPSA test.