I'm waiting for Praulent insurance authorization. May I ask your cost for Praulent? I have a high CAC score and will be getting a stress test/dye next week. My APOE 3/4 allele is probably responsible for my CAC score. My Lp(a) is 115.2 nmol/L, and APOB 91. Since Lp(a) is an independent factor, taking a statin, exercising or dieting will not reduce it, and taking a higher statin can increase your Lp(a) by up to 20%. Cardiologists say Lp(a) is not a plaque burden molecule it's a plaque de-stabilizer and mostly related to the Carotid artery, not CAC scores. I told my Cardiologist I wanted a CIMT (carotid intima-media thickness) sonogram. He said he had no idea where I could get one. PCSK9's reduces Lp(a) up to 32% and LDL up to 70%. siRNA (Leqvio) Can reduce Lp(a) up to 90% and up to 50% for LDL.