There is no cut and dried answer here. Cancer can recur even with an aromatase inhibitor. But you should certainly ask your oncologist directly. The type of breast cancer you have can in part determine risk. If it is low, you might lean towards quitting and if high you'd need to consider it. But speaking as a 70 year-old woman with breast cancer--and many other things!--I definitely include quality of life in my decision making. I kind of look within, weigh the information, and remind myself no decision is perfect--but I can still make a good one for me. Whatever you do, I wish you peace of mind. You might also try another AI if you haven't. I've done fine on letrozole for two years.

Hi @katrii, I moved your question about thumb pain to this discussion in the Breast Cancer Support Group:
- Trigger thumb: What helps?
https://connect.mayoclinic.org/discussion/trigger-thumb/
You may find some helpful tips that members have shared.