Stage 4 Prostate Cancer and Hormone Therapy quit working

I'm sorry to hear that. My cancer team told me that if/when my ADT+Erleada stops working, there are "lots more" things to do these days — those are just the start of the treatment journey, not the end.

If you're doing your own searching, the keywords you want are "metastatic castrate-resistant prostate cancer" (or "mCRPC") — those will give you the most-relevant results.

I assume he's already had radiation to his prostate, but if not, that's one option. If he has only a few metastases ("oligometastatic"), then they can zap them as well; otherwise, there are treatments like Pluvicto for mCRPC that he can take in liquid form to deliver radiation to lots of small metastases internally. Then, of course, there's chemotherapy, PARP-targetting drugs, and probably lots of other treatments I can't think of right now.

I'm looking forward to reading what others post, because this may be in my future as well if/when my stage 4 prostate cancer becomes castrate-resistant.

Zytiga is an option at this point. Usually it is used before Apalutamide but it could be used after. Ask your oncologist. You are working with an oncologist not a urologist, right. Best doctor to get is a Genito urinary oncologist, they specialize in prostate cancer and can give you the best chance for a continuing life.

I was in the Responsive Zone for 2+ years. I am now in the Resistant Zone, started up Oct 23, so I've been in the Resistant Zone for slightly over a year. Both my oncologist aren't worried. We did a PSMA Pet Scan last month, I went from a zillion glowing spots to 9 spots so that's good. I feel great. My local oncologist referred me to radiation to radiate a couple of spine spots. Follow your bliss and may the force be with you.

My husband is on Zytiga and prednisone. It kept his cancer suppressed for three years. You might ask your husband's oncologist about it. There are many options for your husband at this point, so don't despair.

While worrisome, not necessarily time to panic. I say that though I am not there with my PCa so just my perspective given my clinical data and history, one of high risk and aggressive PCa.

From my journey, the advances in treatment options for Advanced and resistant PCa have been exponential since my diagnosis in 2014.

Consider taking time and "reviewing the literature" on advanced PCa and MCRPCa to inform yourselves and serve as a foundation for discussions with your medical team about the way ahead.

Two sites to start with are the Prostate Cancer Foundation - https://www.pcf.org/ and the NCCN - https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1459

He very possibly has a considerable time ahead, albeit with treatment - Chemotherapy, ARIs, PARP Inhibitors... If he has not already, discuss with his medical team having Genomic testing done, it may useful in narrowing treatment choices to his specific clinical data.

Kevin

Your the one who asked me before if I lived in another country as you never heard of Zytiga. Lol. I told you I live in Michigan. Remember?

I started taking Zytiga in January 2021. I definitely was not saying I never heard of it.

Yes, I remember you living in Michigan, I think it was your choices at the time that made me think you were in Canada.

Ok I understand. TY

I’m in your boat—treatment seems to have a effective time expectancy on me—lots of options out there,got about 9mos on hormone, 5 on chemotherapy, just starting nuclear—add in a lot of prayers—-make everyday count—keep plugging along

What nuclear are you starting?

I did Radium 223 for 6 injection fowling a year on Xtandi 2nd chemo caused embolism and fluid on lung Oncology looking at what is next Concerned

Did chemo work? Mine is T 5 L2 and other bone mets Had L1 radiated 2020 80 and feel great Tight breathing

pls answer