I haven't heard of it, but my neck just started cracking recently. Don't really have that issue in too many other places, except my shoulder blade, which has popped for over a decade when I roll it.

Yes, I'm aware of the problem with PPIs including links to Lupus, although my GIs continue to assure me there's nothing wrong with them (I wonder what their cut is), and even had one GI yell at me to stop trying to get off of them unless I wanted cancer.

I've tried for years to stop taking them. Every time, I can get off for a few weeks to a couple of months, and it's pain the entire time, and I eventually just wind up back on them. Luckily I've only taken 1 nexium per day for the last 10 to 20 years, but also periodically stopping for a month or two at a time. But now I'm on 2 a day as of the last few weeks, because my acid issues seems to be worsening. I don't want the surgery, heard it's even worse for you. And I'm 5'6" and 155 lb, not exactly the prime candidate for uncontrolled acid reflux. I guess I'm stuck between a rock and a hard place on this one. And I wonder if my gastric issues are not maybe related to whatever is causing my other problems. My current GI did prescribe me sucralfate, and to be honest, it didn't do a thing for me. I also tried taking double pepcid AC max strength a couple months back, and it almost worked. I was still having a cold sensation after dinner, as if something wasn't quite right, some agitation from acid I guess. I "think" I felt a lot better on Pepcid overall, except for the fact that the acid was still gnawing at my stomach, which at this point I believe has no lining remaining after taking PPIs so long.