I was on the Big 3 for 13 months (with MAC) testing negative the whole time. After being off meds for only 5 months (which was glorious) I got Aspergillus and Abscessus (which was found during a Bronchoscopy). I was beyond disappointed but they wanted to treat the Aspergillus first and I am into 3 months of a 6 month treatment with Voriconazole. I go back to NJH Nov. 3rd so not sure what they plan to do at this point. I try to stay positive but it does get hard at times.