Treatment for metastasis to the lungs?

Actually, I’ll be on chemo for 2 week back to back sessions until determined otherwise.

Hi gamaryanne! You mention a cohort doing RMC6236 and chemo at the same time - do you know where this is happening? Is it a trial that is open to new members?

I had metastasis to my lungs. Treated with gemcitabine & abraxane for 44 treatments; 4 months off and now have had 12 more treatments. My lung nodules have been stable with the gemcitabine & abraxane even with the 4-month break. I have the KRAS G12D and TP 53 genes.

@199
That’s a lot of treatments! Over how many years was the course of your 44 treatments? So good to hear your nodules are stable. Did you ever consider the MRIdean radiation on those nodules? Yes, bronchoscopy was rough, I don’t think I would recommend other cancer patients to go forward with one especially if you already have underlying respiratory issues like I do. Although, my nodules didn’t look characteristic of typical cancer nodules (morphology) I was told; so I guess it was good to know one way or the other.

I was told in June 2022 that I was lucky I had stage 1 and after the mri, Ct and labs, I was told at the end of June via a zoom call that I was stage 4 and would only make it 2-4 months with and 11 months without treatment & to find a local oncologist. Two days (July 2022) later I had my local oncologist appointment & he said prognosis varies on how you respond to treatment. After my port he started me on Gemcitabine and Abraxane with Decadron & Aloxi prior to the infusions. I started with 2 weeks on and one off for many months until I got so fatigued & he changed it to one week on and one off. I did that until Dec. 2023 & took off for 4 months. My CA 19-9 had already started to rise from a low of 8 in Feb. of 2023 and made it over 300 by April 2024. I started back on the same treatment regime and will have my 13th treatment this time around on Thursday. I have not had a discussion about MRI radiation to the nodules since they responded so well to the Gemcitabine/Abraxane. I was offered a bronchoscopy by my pulmonologist. I discussed this with my oncologist. He would not change treatment plan so there was no point in "disturbing the mothership" by poking it since it responded to tx & did not need diagnosing since it was responding to the G/A. At the beginning of Oct I was 0.1 CA19-9.

Got my biopsy results and my lung nodule even though it grew fairly quickly is not cancer. However, a blood clot in my lungs was discovered and I’m taking g my medication for it. Did the bronchoscopy cause the clot? I’ll never know. At least it’s not lung cancer, but I do have a harder time breathing now then I did before the bronchoscopy. Carrying on.

@mnewland99
So glad the nodule was not cancer! It seems more and more we hear of lung nodules that are “probably not cancer-but let’s check”. Of course, once we join the C club, one thing seems to beget another.

How long until they can recheck the status of the blood clot?

Glad you are staying vigilant. This too shall pass.

Thank you, Maryanne!
Yes, so glad nodules not cancerous! No medical staff told me much about the blood clot, I assumed since it was small that it would be dissolved with the IV blood thinners they were giving me in the hospital. Found out this week it can take weeks or even months to dissolve. I was suppose to have a PET scan as a F/U for possible cancer in femur they saw a few months ago, but it had to be postponed as it was the same day they found my blood clot. Maybe that will see something, but as far as know they don’t really do imaging to recheck if blood clots still present. How are you doing with the clinical trying you are on? We are all rooting for you!! 👏

Well… two weeks ago my ca19-9 was 31!

Today I’m going to a conference on Pcan. It’s CE credit for medical professionals (which I am not!) so perhaps I will learn something new of value. If so, I will share.

@gamaryanne I’m so happy to hear that your tumor marker is within normal limits now! That’s such a good feeling. Last check mine was under 37, but climbing, though I’ve probably had a lot of inflammation lately due to some allergic activity going on in my lungs which my pulmonologist says is environmental in origin. Cannot wait until the trial you are on comes to the west coast! Thank you for the feedback on it that you have provided. I’m always amazed of the ingenious ways you have acquired knowledge about this disease such as going to conferences and being on top of the latest information. Please update us on any news worthy of sharing that you get from the conference.