1. < Breast Cancer

Estrogen Blocking Medications, age and risk of blood clots

Posted by rylee2019 @rylee2019, Oct 27 2:44pm

Has anyone been told that they don't need to take estrogen blocking meds even though they were estrogen positive because they are at a higher risk of blood clots because of their age ( 72).

Thanks!

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gigipatula | @gigipatula | Oct 27 3:12pm

When I was 65 with ER/PR+ breast cancer I was told to take them, however I chose not to because it was only a slight decrease for recurrence for my tumor parameters. However interestingly enough there is a study that over the counter Claritin and one other H1 antihistamine helps with preventing recurrence. Do some research, the side affects of the AI's and Tamoxifen are real and really need to be weighed against the benefits. Link to article below, I'm more than happy to take Claritin aka generic Lortadine every night before bed time, only side affect is I get a good nights sleep 🙂
https://pubmed.ncbi.nlm.nih.gov/32459128/

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1 reply
windyshores | @windyshores | Oct 27 6:33pm

@rylee2019 Tamoxifen, usually used pre-menopause but not always, brings an increase in risk for blood clots. I wasn't aware of that risk with aromatase inhibitors. I looked it up and studies vary in their conclusion but most say that the risk is "milder" with AI's than with tamoxifen. What kind of specialist told you that at 72 you could not do an AI? Have you talked with an oncologist about this? Is this precaution based on some assumption about your life span?

Here is one example:
Results: We identified 623 VTE events during a median follow-up of 5.4 years. The crude rates were 4.6 and 2.8 per 1000 person-years for DVT and PE, respectively. Compared with tamoxifen use, AI use was associated with at least 41% lower VTE risk (adjusted HR 0.59, 95% CI 0.43, 0.81). Greater risk reductions in AI users were seen in women who also underwent adjuvant chemotherapy.

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1 reply
rylee2019 | @rylee2019 | Oct 27 6:52pm
In reply to @windyshores "@rylee2019 Tamoxifen, usually used pre-menopause but not always, brings an increase in risk for blood clots...." + (show)
@windyshores

@rylee2019 Tamoxifen, usually used pre-menopause but not always, brings an increase in risk for blood clots. I wasn't aware of that risk with aromatase inhibitors. I looked it up and studies vary in their conclusion but most say that the risk is "milder" with AI's than with tamoxifen. What kind of specialist told you that at 72 you could not do an AI? Have you talked with an oncologist about this? Is this precaution based on some assumption about your life span?

Here is one example:
Results: We identified 623 VTE events during a median follow-up of 5.4 years. The crude rates were 4.6 and 2.8 per 1000 person-years for DVT and PE, respectively. Compared with tamoxifen use, AI use was associated with at least 41% lower VTE risk (adjusted HR 0.59, 95% CI 0.43, 0.81). Greater risk reductions in AI users were seen in women who also underwent adjuvant chemotherapy.

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Thank you Windyshores. I had DCIS stage 0, grade 3 in 2 areas in my left breast. I had a bilateral mastectomy with expanders in August, 3 lymph nodes removed - clean margins and no spread. No radiation or chemo needed. It seems that other women have been on the meds when they are ER+ so I asked my oncologist why they were not prescribed and she said due to the risk of blood clots with my age. I may need to go to different oncologist for another opinion.

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1 reply
windyshores | @windyshores | Oct 27 7:02pm
In reply to @rylee2019 "Thank you Windyshores. I had DCIS stage 0, grade 3 in 2 areas in my left..." + (show)
@rylee2019

Thank you Windyshores. I had DCIS stage 0, grade 3 in 2 areas in my left breast. I had a bilateral mastectomy with expanders in August, 3 lymph nodes removed - clean margins and no spread. No radiation or chemo needed. It seems that other women have been on the meds when they are ER+ so I asked my oncologist why they were not prescribed and she said due to the risk of blood clots with my age. I may need to go to different oncologist for another opinion.

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I would have the Oncotype for DCIS done to see what your risk is with and without meds.

I had 4 opinions with my invasive cancer 🙂

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ebtexas55 | @ebtexas55 | Oct 27 8:42pm

I havent been told that, but a natural blocker is yam or progesterone cream and several species of mushrooms.

Be sure your cancer didnt feed off progesterone.
Look at the Late Dr John Lees books or search him.

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ebtexas55 | @ebtexas55 | Oct 27 8:46pm
In reply to @gigipatula "When I was 65 with ER/PR+ breast cancer I was told to take them, however I..." + (show)
@gigipatula

When I was 65 with ER/PR+ breast cancer I was told to take them, however I chose not to because it was only a slight decrease for recurrence for my tumor parameters. However interestingly enough there is a study that over the counter Claritin and one other H1 antihistamine helps with preventing recurrence. Do some research, the side affects of the AI's and Tamoxifen are real and really need to be weighed against the benefits. Link to article below, I'm more than happy to take Claritin aka generic Lortadine every night before bed time, only side affect is I get a good nights sleep 🙂
https://pubmed.ncbi.nlm.nih.gov/32459128/

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Thank you!
Researching it.👍🏼👏🏻

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1 reply
gigipatula | @gigipatula | Oct 28 9:49am
In reply to @ebtexas55 "Thank you! Researching it.👍🏼👏🏻" + (show)
@ebtexas55

Thank you!
Researching it.👍🏼👏🏻

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You're welcome! And another study associates Claritin (not Claritin D) with helping women who do take AI's with joint aches and pains.

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