← Return to Estrogen Blocking Medications, age and risk of blood clots

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@windyshores

@rylee2019 Tamoxifen, usually used pre-menopause but not always, brings an increase in risk for blood clots. I wasn't aware of that risk with aromatase inhibitors. I looked it up and studies vary in their conclusion but most say that the risk is "milder" with AI's than with tamoxifen. What kind of specialist told you that at 72 you could not do an AI? Have you talked with an oncologist about this? Is this precaution based on some assumption about your life span?

Here is one example:
Results: We identified 623 VTE events during a median follow-up of 5.4 years. The crude rates were 4.6 and 2.8 per 1000 person-years for DVT and PE, respectively. Compared with tamoxifen use, AI use was associated with at least 41% lower VTE risk (adjusted HR 0.59, 95% CI 0.43, 0.81). Greater risk reductions in AI users were seen in women who also underwent adjuvant chemotherapy.

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Replies to "@rylee2019 Tamoxifen, usually used pre-menopause but not always, brings an increase in risk for blood clots...."

Thank you Windyshores. I had DCIS stage 0, grade 3 in 2 areas in my left breast. I had a bilateral mastectomy with expanders in August, 3 lymph nodes removed - clean margins and no spread. No radiation or chemo needed. It seems that other women have been on the meds when they are ER+ so I asked my oncologist why they were not prescribed and she said due to the risk of blood clots with my age. I may need to go to different oncologist for another opinion.