Connect
← Return to Anyone on Piqray (alpelisib) for breast cancer with Pik3 mutation?
Discussion
Anyone on Piqray (alpelisib) for breast cancer with Pik3 mutation?
Breast Cancer | Last Active: Nov 3, 2023 | Replies (12)Comment receiving replies
I’ve been on Ribociclib and Faslodex for past 15 months for liver metastasis
July 2023. At that time I had one liver lesion that was ablated. I have had MRIs every 6months and they were negative for cancer. (June MRI was negative). Two weeks ago three new small liver lesions were noted on MRI. This was also accompanied by rising CA 27.29 and rising signatera. A liquid biopsy was also sent that I am awaiting results.
Oncologist is starting me on Piqray as I have the PIK3 mutation. I’ve done research on this drug and am very concerned about the high incidence of hyperglycemia necessitating using Metformin.
I would appreciate any feedback from women who have or current are taking this drug.
Feeling very frustrated and disappointed. ☹️
Replies to "I’ve been on Ribociclib and Faslodex for past 15 months for liver metastasis July 2023. At..."
Yes! This sounds exactly like my story! One liver lesion for a year. Had a Y90 in June. Latest scan now I have over 11 all spread throughout my liver. Also spread elsewhere . I was on Kisquali and Faslodex for 12 cycles.
Piqray started 4 weeks ago, My sugars were pretty high after 2 weeks. I am also on a Decadron Steriod for a met they found in cranial nerve giving me pain which also raises sugar. Hoping it will go down a bit after steriod done. Otherwise I have not noticed any other side effects. I also added Zyrtec to slow down and rash that may pop up since that is common and I always have sensitive skin.
Bought a glucose meter and now taking 2 pills of metformin daily to start. My sugars are still high but not as bad. I am certainly watching what I eat and met with a cancer nutritionist thru Unite For Her. She was very helpful. And now keeping busy on looking at fun recipes to make with out sugars.
Good luck to us!
Connect
Hello @hikerlou , I am not on this drug but I didn’t want to leave you unanswered. Living with advanced cancer is never ever easy, and I somewhat know what you are going through right now. Every relapse is a letdown and adds more fear and frustration.
I can’t tell you what you should do because only you know your situation health and quality of life. I can only tell you what I would consider in my situation. I would weigh how I feel now, with how I will feel if I don’t try it. I have had quite a few relatives on metformin, as diabetes runs in my family. It really isn’t bad, I just texted a friend and she said if that is the worst part she would go for it. She has been on it (metformin) for years with no problems.
My question would be is there a benefit to the current Mets, and can it help prevent new ones? How will my quality of life be, will I be able to do the things I love? I can try and then quit if it is awful and not helping, right?
All of that being said, I am heartbroken over every relapse of a breast cancer patient, regardless of stage. Did you decide to try Piqray? When do you expect your biopsies to be back?