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Sed Rate still elevated, but pain much improved
Polymyalgia Rheumatica (PMR) | Last Active: Oct 27 11:01am | Replies (18)Comment receiving replies
@dadcue, this is really interesting about the interplay between osteoarthritis and PMR. I first had severe lumbar spinal pain (sciatica) about six months before PMR diagnosis, when MRI revealed spinal stenosis and many herniated discs. Diagnoses of shoulder, neck and knee arthritis soon followed. I was surprised to learn these issues had been developing for a good while with no symptoms, so it does seem likely the PMR contributed to the OA pain rearing its ugly head. Can you send us the link to the article you quoted about CRP playing a role in OA development?
Replies to "@dadcue, this is really interesting about the interplay between osteoarthritis and PMR. I first had severe..."
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The study was done with mice. But the quote pertained to humans.
https://www.sciencedirect.com/science/article/pii/S1063458418314730#:~:text=C%2Dreactive%20protein%20(CRP)
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There is evidence that inflammatory biomarkers are elevated in osteoarthritis in humans. The title of the following link is: Inflammatory Biomarkers in Osteoarthritis
"In recent years, there has been a large shift in the understanding of OA as a “wear and tear” disease to an inflammatory disease."
https://pmc.ncbi.nlm.nih.gov/articles/PMC4630669/#:~:text=SF%20levels%20of%20IL%2D6,of%20healthy%20controls(94).
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My personal experience with arthritis is the following:
I developed degenerative osteoarthritis in one knee caused by a sports injury in high school. At the age of 25, I was told that I needed a knee replacement but I had to wait until I was 60 years old to do a knee replacement.
An autoimmune inflammatory arthritis called "reactive arthritis" was diagnosed when I was 32 years old. This inflammatory arthritis liked to attack my spine. However, the inflammation wasn't confined to my spine.
https://www.niams.nih.gov/health-topics/reactive-arthritis
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PMR was diagnosed when I was 52. When PMR was diagnosed, I had shoulder pain that hurt so much that I couldn't lift my arms. I also had "generalized" body pain but I told my rheumatologist that some of the places that hurt were always painful. The shoulder pain was something new and the acute onset and high ESR and CRP along with a rapid response to prednisone was the basis for diagnosing PMR. The rapid response to prednisone alone wasn't diagnostic of PMR because I would say my reactive arthritis flares responded faster to prednisone than PMR did. I never needed to take Prednisone on a long term basis to treat flares of reactive arthritis. However, my rheumatologist said reactive arthritis wasn't treated with prednisone.
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Now I have severe lumbar spinal stenosis that is called "degenerative osteoarthritis" but my spine was where my autoimmune reactive arthritis liked to attack the most. When spinal stenosis was diagnosed, I had acute onset neurological changes along with radicular leg pain (sciatica). An MRI revealed the severe spinal stenosis. I told a spine surgeon that I didn't know I had a "bad back." The surgeon said the kind of damage I had didn't happen overnight. He asked me if I ever had back pain but I said I didn't have any pain when I took prednisone.
I now have arthritis everywhere they look. My shoulders don't hurt anymore and seem to be unscathed. I don't think I have any arthritis in my shoulders.