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Orgovyx and zytiga side effects

Prostate Cancer | Last Active: Mar 3 9:52am | Replies (40)

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Profile picture for jeff Marchi @jeffmarc

I have found constipation is quite common when taking prostate cancer drugs, not just Orgovyx.

I’ve been been taking three senna and two colace twice a day for a few years to offset the constipation. Sometimes I even need to take MiraLAX, but not very often.

Stopping Orgovyx could result in you having your cancer come back very quickly. You’ll get the same results with Lupron or Eligard. It’s just something you have to live with, with prostate cancer drugs.

The NCCN standard calls for you to be on ADT for six months, not four.

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Replies to "I have found constipation is quite common when taking prostate cancer drugs, not just Orgovyx. I’ve..."

Jeffmarc,
Thanks so much for the information. So you have been taking 6 senna and four Colace pills a day, plus occasionally some MiraLAX, for a few years with, I assume, no negative effects. That it really helpful for me to hear. I guess I don't need to be so afraid of those higher doses damaging my colon. I discussed my constipation with my Radiation Oncologist before starting down this path and she made it clear she requires a clean colon to administer the radiation to the prostate. I'll ask her about the NCCN standard. Curiously, before my cardiologist cleared me for ADT, my RO told me I would be fine with no ADT, just radiation. She said ADT would accelerate my atherosclerosis. Once my cardiologist cleared me for ADT, ADT became necessary... Thanks again!

Is that Sennacot you mention? Myself,Lupron and Abiratone with Prednisone and suffer from major constipation. Need quarts of prune juice and senna to help, but both take time 12 hours to work. Metamucil at times may or may not work. Causes head aches and constant insomnia too, I feel. BM"s maybe once or twice a week if lucky. Therapy for PC really sucks big time as to SE's. Been through the grinder since diagnosis at 71 2/2019 RP ,RT, salvage, Lupron. Quit first round 2/2022 of this nasty stuff then quit second sesson 2/2025 both due to SE's Still taking Abiratone and Prednisone and hoping SE's fade as Lupron lreaves my system Any feedback on constipation issues most welcome.
Thanks,
SEW