← Return to PSE Test for Prostate Cancer Before an MRI and for Re-Occurrence

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@bens1

@northoftheborder here is what Steve Arrivo just emailed me: “ PSE is a perfect test to show prostate treatment(s) were effective: focal ablation, prostatectomy, proton therapy, etc. as the cancer should be removed and therefore none detected. We have seen men with prostatectomies as far as 10 years out with a rising PSA and they have shown a high likelihood of cancer being present (which as we discussed is greater than 90% accurate – positive predictive value = 93%).”

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Replies to "@northoftheborder here is what Steve Arrivo just emailed me: “ PSE is a perfect test to..."

Thanks -- that's helpful.

Did he say what the additional predictive value was over rising PSA alone after a radical prostatectomy or major radiation?

I can see the value of a testing refinement after highly-focussed treatment like proton therapy or a focal ablation, when enough of the prostate still functions that rising PSA could be harmless, but if they've completely removed the prostate or fried it thoroughly a high dose of photon-based EBRT, then I'd think any rising PSA is automatically cause for concern (since we know it's not coming from the prostate), and the main value of adding epigenetic testing would be to confirm that epigenetic testing works.