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Letrozole joints, bone loss, low platelets, high cholesterol
Breast Cancer | Last Active: Nov 1 6:54pm | Replies (35)Comment receiving replies
@flowergal did you mean your ER% is low? If so maybe you can ask your oncologist if an AI is that helpful in the context of lower response due to lower ER%.
Just wanted to also say that on the osteoporosis forum there is a lot of discussion about the difficulties in getting off Prolia: there is a "rebound" with loss of bone density and increase in fracture risk. Some experts (McCormick, Leder for example) suggest either doing Reclast or Zometa instead. If you do 1-3 shots of Prolia you apparently could do Reclast/Zometa (they are both zoledronic acid) or oral Fosamax. If you do longer term Prolia then Reclast is needed to prevent rebound. I am just suggesting this concern as an osteoporosis sufferer, so ask your doctor about rebound and the best way to deal with both bone loss from cancer meds and potential rebound from Prolia.
Replies to "@flowergal did you mean your ER% is low? If so maybe you can ask your oncologist..."
I just looked it up ER+
"15% weak"
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Yes I had a low ER + number but was told any positive result should be treated. My original biopsy was not positive but the surgical pathology were a low positive.
I met with a rheumatologist and a Endocrinologist and yesterday I spoke with my new GP. Who is a brilliant young lady. We discussed Prolia because I had to get two shots in 2019 and my numbers stayed good in 2022. The numbers now are much worse since being on AI's since last December.
I had no problems with the drugs in 2019. All the Doctors think Prolia for next three years then reclast. I am a little comforted by the fact my brother was on Prolia for several years. He apparently inherited this too.
I appreciate your response. I have to re look up my ER % before I talk to Doctor and ask her to remind me of the reoccurrence % without AI. I don't think it was super high.
It's so much more complicated than I was led to believe. My oncologist told me this would be a "blip" in my life. I feel mislead.
Thank you for the informative response. I want to keep helping take care of my grandchildren.