I had the same thought….but I remember my urologist telling me that sometimes the surgeon will leave some healthy prostate tissue in place for nerve sparing issues.
That tissue will produce PSA and could point to a false biochemical relapse, thereby calling for salvage treatment which isn’t necessary.
In my case it was the PSA velocity which put me into salvage status but with this new test maybe that could have been avoided??
Guess I’ll never know but I would be in favor of any test which cuts down on excessive treatment and side effects.

Hi, thanks for your reply. Just to clarify, the EpiSwitch PSE test analyses immune cells in the blood that have been at interplay with prostate cancer (or not). Your PSA value only makes up a small portion of the results of the test. There are other very informative biomarkers assessing the presence or absence of PCa included in this test. So yes, EpiSwitch PSE can still be used with a very low PSA score, and can still detect prostate cancer without PSA shedding. Therefore, the test can be used before, after and during treatment - even after complete prostate resection. In your case, a 'low likelihood' result could potentially help you avoid things like PSMA scans if your PSA indeed rises over time. A 'high likelihood' result could be indicative of recurrence, irrespective of low PSA.