@gently and @njx58 the black box warning was lifted for Tymlos but not the two year limit. They are not the same thing.

It took a lot of money and patients and time to lift the two year limit on Forteo and I have read that it is doubtful that Radius will do the same for Tymlos.

That doesn't mean some doctors aren't doing more than 2 years but the limit is still on.

@rjx58 my bone markers would have seemed to indicate Tymlos was no longer that effective after 18 months and both my endos agreed. I stayed on another 6 months while I decided on next steps and both endos told me that would at least keep me steady.

Some on this forum have suggested that after a break, these anabolics might be effective again. I speculate that we will be doing shorter courses of these as well as Evenity with some bisphosphonates in between, possibly, so that we can get the most out of whatever time limit we are dealing with and also stretch treatment out. But who know.