The main product ingredient is ivermectin. There has been no studies that have shown that ivermectin has actually been beneficial in treating prostate cancer.
Colleen Young, Connect Director | @colleenyoung | Oct 18 2:59pm
@tstump12, eprinomectin is a member of a family of drugs called avermectins. It is a derivative of ivermectin used in veterinary medicine to treat a variety of gastrointestinal roundworms in cattle and for topical use in horses and rabbits.
Researchers are studying eprinomectin as well as ivermectin to see if it may be used as an anti-cancer drug and early studies show promise. IMPORTANT: this research is in the early stages (laboratory cellular and mice studies) and has not yet been tested in human trials.
- Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells by targeting the β-catenin signaling pathway https://pubmed.ncbi.nlm.nih.gov/37171616/
Ivermectin and eprinomectin are not proven standard treatments for prostate cancer.
Have you talked to your oncologist about the use of eprinomectin?
I have not talked to anyone about it. However I am preparing for the return of my cancer as my decipher just came back at .87 and I am looking for a drug with the least side effects. Anyone have a recommendation? Thanks.
It’s another veterinary antiparasitic similar to ivermectin and others.
While all of these show good results in the lab there have not been any double blind studies or human trials.
You will find many anecdotal comments from people saying they’ve used it successfully, or a friend did, or a friend of a friend, etc.
I wish they really WOULD offer these agents to those willing to try them in lieu of other treatments but the FDA is a big obstacle and no MD is gonna risk his license treating patients outside the standard of care. Hopefully, this will change!
I have not talked to anyone about it. However I am preparing for the return of my cancer as my decipher just came back at .87 and I am looking for a drug with the least side effects. Anyone have a recommendation? Thanks.
It’s hard to recommend anything when you’ve supplied no information about what’s going on with your cancer.
What treatment did you have? What was your Gleason score and PSA at diagnosis? True, your decipher results do not look good but you still have a long time ahead of you, just make sure to get treatment, not avoid it.
Mine has come back multiple times, but there’s always another treatment.
I have not talked to anyone about it. However I am preparing for the return of my cancer as my decipher just came back at .87 and I am looking for a drug with the least side effects. Anyone have a recommendation? Thanks.
Iodine (more advanced should use, not for everyone)
The Link Between Prostate Cancer and Iodine https://www.biowarriornutrition.com/blogs/blog-page/the-link-between-prostate-cancer-and-iodine
A prospective study of iodine status, thyroid function, and prostate cancer risk: follow-up of the First National Health and Nutrition Examination Survey https://pubmed.ncbi.nlm.nih.gov/17571964/
Iodine Uptake and Prostate Cancer in the TRAMP Mouse Model https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883964/
Use with physicians help only. Just be aware the taking of iodine and not having good or adequate selenium levels is a known trigger to cause Hashimoto's disease. So that means if you choose to take iodine, have your primary care run a selenium lab first because if it is deficient that can cause a bad outcome.
Then there is this for those with BPH leading up to prostate problems, supplements and info that might help some
Testosterone / estrogen ratios
Have a holistic doctor, naturopath, primary care, or other doctor order labs for you and hopefully have useful suggestions. A good testosterone to estrogen ratio for a male that is 40 or older should be around 10, though it is much higher in younger men. That is 10 times more testosterone than estrogen or 10:1. Better than 10 is good, 8-10 is in-between or just adequate, and if ratio is quite a bit lower there are some things you can do.
Symptoms of poor Testosterone / estrogen ratio in men include (you won’t have all of this just some are likely):
• BPH and sometimes prostate cancer follows
• Low libido
• Hair loss
• Weight gain & body fat
• Gynecomastia (“man-boobs”)
• Erectile dysfunction
• Muscle loss
• Fatigue
Things to do - knowing we are people with prostate problems including PCa.
• If PCa and BPH, don’t take exogenous testosterone (like injections) unless approved by physicians, so only work on natural was to raise the Testosterone portion of the ratio. That would mean exercise, controlling blood sugar, solving any zinc deficiency.
• Try things to lower estrogen. Some natural ways are cruciferous vegetables. Supplements include Sulforaphane glucosinolate (SGS) and DIM as these derive from cruciferous vegetables. Be sure the DIM and SGS work right for you, as they may not always do the job or an inadequate one. My experience is these don’t work that well.
• Avoid plastic touching food especially hot food, as it has “xenoestrogens” which to the body are just like estrogen. That means dump all plastic storage containers, especially older ones.
• Talk to your doctor about progesterone as it is a truly natural anti-estrogen but only if ratios are really bad. It is available OTC as well, but you need a very small amount daily with breaks from time to time. Use a low dose suitable for men and doctors ordering labs to help, so it does require a doctors help for that. Trans-mucosal progesterone may produce best results. Progesterone Powder USP, Bioidentical Micronized Powder can be dissolved into tiny amounts determined via a measuring spoon. For men 1/64 tsp (need a tiny measuring spoon), dissolve in a cut open 100 IU Vitamin E liquid capsule and onto a regular table spoon. Apply transmucosal or on gum area of mouth.
It’s hard to recommend anything when you’ve supplied no information about what’s going on with your cancer.
What treatment did you have? What was your Gleason score and PSA at diagnosis? True, your decipher results do not look good but you still have a long time ahead of you, just make sure to get treatment, not avoid it.
Mine has come back multiple times, but there’s always another treatment.
I had a prostectomy one year ago. Gleason is 4+4 and psa is still reading .05 and I am 79 years old. Any advice on proton therapy vs drugs would be appreciated also.
A PSA of .05 is considered undetectable by NCCN and most treatment centers. At this point, you have nothing to worry about. If it hits .2 then doctors get interested in radiation treatments. Yours could bounce around for years and never hit .2..
Once it hits .2 many doctors will want to do salvage radiation and put you on Lupron/Orgovyx or similar drugs. You don’t do it until you get a reoccurrence and you don’t have that.
Took me 3 1/2 years to go from surgery to reoccurrence. Yes you have a Gleason 8, but I know people with Gleason 8 and higher that haven’t had a recurrence for a decade.
IMO, Jeffmarc has given you the best advice possible. NOTHING is going to change the course of your cancer; no supplement, no mineral, no roots from China. It is total BS at the stage and AGE you are at.
Maybe if you were born now and had the absolute healthiest lifestyle possible and the best possible non-mutable genes - and took all the supplements, tinctures, teas and pills holistic medicine has to offer MAYBE MAYBE MAYBE you might have some effect on your cancer.
But after a lifetime of 70+ years, exposed to carcinogens you are not even aware of and eating a diet that was probably less than optimal, you got what you got and now it’s time to allow many decades of sound medical research help you live a lot longer.
Your PSA, as pointed out, is far from the .2 necessary for treatment and even though your Decipher score is suggesting a more aggressive form of cancer, ADT is an incredibly powerful tool for preventing its spread, and side effects in most cases - especially at your age (sorry, but them’s the facts) are not too tough to deal with.
Of course, it’s always your choice and YOU will be the one who decides. I only caution against losing valuable time dicking around with unproven remedies; don’t be another Steve Jobs, a man who always thought he was the smartest guy in the room and died because he wasted over a year using unproven herbs, roots, etc. By the time he had surgery, it was too late. Best to you!
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The main product ingredient is ivermectin. There has been no studies that have shown that ivermectin has actually been beneficial in treating prostate cancer.
@tstump12, eprinomectin is a member of a family of drugs called avermectins. It is a derivative of ivermectin used in veterinary medicine to treat a variety of gastrointestinal roundworms in cattle and for topical use in horses and rabbits.
Researchers are studying eprinomectin as well as ivermectin to see if it may be used as an anti-cancer drug and early studies show promise. IMPORTANT: this research is in the early stages (laboratory cellular and mice studies) and has not yet been tested in human trials.
- Eprinomectin: a derivative of ivermectin suppresses growth and metastatic phenotypes of prostate cancer cells by targeting the β-catenin signaling pathway https://pubmed.ncbi.nlm.nih.gov/37171616/
Ivermectin and eprinomectin are not proven standard treatments for prostate cancer.
Have you talked to your oncologist about the use of eprinomectin?
-
Like -
Helpful -
Hug
1 ReactionI have not talked to anyone about it. However I am preparing for the return of my cancer as my decipher just came back at .87 and I am looking for a drug with the least side effects. Anyone have a recommendation? Thanks.
It’s another veterinary antiparasitic similar to ivermectin and others.
While all of these show good results in the lab there have not been any double blind studies or human trials.
You will find many anecdotal comments from people saying they’ve used it successfully, or a friend did, or a friend of a friend, etc.
I wish they really WOULD offer these agents to those willing to try them in lieu of other treatments but the FDA is a big obstacle and no MD is gonna risk his license treating patients outside the standard of care. Hopefully, this will change!
-
Like -
Helpful -
Hug
1 ReactionIt’s hard to recommend anything when you’ve supplied no information about what’s going on with your cancer.
What treatment did you have? What was your Gleason score and PSA at diagnosis? True, your decipher results do not look good but you still have a long time ahead of you, just make sure to get treatment, not avoid it.
Mine has come back multiple times, but there’s always another treatment.
-
Like -
Helpful -
Hug
2 ReactionsJust some supplements, they may or not help you or anyone, but they have some small study at least.
----
Boron
Boron Reduces Prostate Cancer Risk
Nothing Boring About Boron
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712861/
"has demonstrated preventive and therapeutic effects in a number of cancers, such as prostate, cervical, and lung cancers, and multiple and non-Hodgkin’s lymphoma"
Dietary boron intake and prostate cancer risk
https://pubmed.ncbi.nlm.nih.gov/15010890/
http://www.lifeextension.com/Magazine/2015/11/Boron-Reduces-Prostate-Cancer-Risk/Page-01
Brand examples: Trace Minerals Boron (liquid). Lower cost.
---
CLA and modified citrus pectin
https://pubmed.ncbi.nlm.nih.gov/14976130/
Both discussed:
https://www.lifeextension.com/magazine/1999/10/report4
Brand examples: Bronson CLA (low to mid cost), Swanson modified citrus pectin (somewhat high cost)
---
Neem, Ginger
Neem and Ginger are mentioned in articles for PINs (precursor to PCa), and might be helpful but not proven in any large study for PCa. They may or not help with BPH.
Ginger
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426621/
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22611
Neem
Neem components as potential agents for cancer prevention and treatment
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734358/
Consumption of a bioactive compound from Neem plant could significantly suppress development of prostate cancer
https://www.sciencedaily.com/releases/2016/09/160929082202.htm
Brand examples: PLNT by VitaminShoppe. In general lower cost.
---
Crinum Latifolium- Asymptomatic inflammatory Prostatitis , BPH, anti-cancer potential
Crinum Latifolium Leave Extracts Suppress Immune Activation Cascades in Peripheral Blood Mononuclear Cells and Proliferation of Prostate Tumor Cells:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134856/
Overview:
https://herbalteashinesun.blogspot.com/2016/09/medicinal-uses-bulbs-and-leaves-of.html?m=1
Crinum Latifolium: Traditional Vietnamese Herb Shows Great Promise for Prostate & Ovarian Health
http://imagesandprostate.blogspot.com/2008/08/crinum-hope-prostate-and-ovarian.html
3 Brand examples: Florida Herbal Pharmacy, Get Well Natural, Crila. All very expensive.
---
Lycopene
The Potential Role of Lycopene for the Prevention and Therapy of Prostate Cancer: From Molecular Mechanisms to Clinical Evidence
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742263/
Lycopene effects contributing to prostate health
https://pubmed.ncbi.nlm.nih.gov/20155615/
Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review
https://www.nature.com/articles/pcan200938
---
Oregano Oil / Carvacrol
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075627/
Carvacrol, is a component of oregano.
https://www.bensnaturalhealth.com/blog/oregano-benefits/
---
Graviola/Soursop (fruit or leaf tea)
https://www.webmd.com/cancer/graviola-cancer-overview
----
Iodine (more advanced should use, not for everyone)
The Link Between Prostate Cancer and Iodine
https://www.biowarriornutrition.com/blogs/blog-page/the-link-between-prostate-cancer-and-iodine
A prospective study of iodine status, thyroid function, and prostate cancer risk: follow-up of the First National Health and Nutrition Examination Survey
https://pubmed.ncbi.nlm.nih.gov/17571964/
Iodine Uptake and Prostate Cancer in the TRAMP Mouse Model
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883964/
Use with physicians help only. Just be aware the taking of iodine and not having good or adequate selenium levels is a known trigger to cause Hashimoto's disease. So that means if you choose to take iodine, have your primary care run a selenium lab first because if it is deficient that can cause a bad outcome.
-
Like -
Helpful -
Hug
2 ReactionsThen there is this for those with BPH leading up to prostate problems, supplements and info that might help some
Testosterone / estrogen ratios
Have a holistic doctor, naturopath, primary care, or other doctor order labs for you and hopefully have useful suggestions. A good testosterone to estrogen ratio for a male that is 40 or older should be around 10, though it is much higher in younger men. That is 10 times more testosterone than estrogen or 10:1. Better than 10 is good, 8-10 is in-between or just adequate, and if ratio is quite a bit lower there are some things you can do.
Symptoms of poor Testosterone / estrogen ratio in men include (you won’t have all of this just some are likely):
• BPH and sometimes prostate cancer follows
• Low libido
• Hair loss
• Weight gain & body fat
• Gynecomastia (“man-boobs”)
• Erectile dysfunction
• Muscle loss
• Fatigue
Things to do - knowing we are people with prostate problems including PCa.
• If PCa and BPH, don’t take exogenous testosterone (like injections) unless approved by physicians, so only work on natural was to raise the Testosterone portion of the ratio. That would mean exercise, controlling blood sugar, solving any zinc deficiency.
• Try things to lower estrogen. Some natural ways are cruciferous vegetables. Supplements include Sulforaphane glucosinolate (SGS) and DIM as these derive from cruciferous vegetables. Be sure the DIM and SGS work right for you, as they may not always do the job or an inadequate one. My experience is these don’t work that well.
• Avoid plastic touching food especially hot food, as it has “xenoestrogens” which to the body are just like estrogen. That means dump all plastic storage containers, especially older ones.
• Talk to your doctor about progesterone as it is a truly natural anti-estrogen but only if ratios are really bad. It is available OTC as well, but you need a very small amount daily with breaks from time to time. Use a low dose suitable for men and doctors ordering labs to help, so it does require a doctors help for that. Trans-mucosal progesterone may produce best results. Progesterone Powder USP, Bioidentical Micronized Powder can be dissolved into tiny amounts determined via a measuring spoon. For men 1/64 tsp (need a tiny measuring spoon), dissolve in a cut open 100 IU Vitamin E liquid capsule and onto a regular table spoon. Apply transmucosal or on gum area of mouth.
-
Like -
Helpful -
Hug
1 ReactionI had a prostectomy one year ago. Gleason is 4+4 and psa is still reading .05 and I am 79 years old. Any advice on proton therapy vs drugs would be appreciated also.
-
Like -
Helpful -
Hug
1 ReactionA PSA of .05 is considered undetectable by NCCN and most treatment centers. At this point, you have nothing to worry about. If it hits .2 then doctors get interested in radiation treatments. Yours could bounce around for years and never hit .2..
Once it hits .2 many doctors will want to do salvage radiation and put you on Lupron/Orgovyx or similar drugs. You don’t do it until you get a reoccurrence and you don’t have that.
Took me 3 1/2 years to go from surgery to reoccurrence. Yes you have a Gleason 8, but I know people with Gleason 8 and higher that haven’t had a recurrence for a decade.
-
Like -
Helpful -
Hug
4 ReactionsIMO, Jeffmarc has given you the best advice possible. NOTHING is going to change the course of your cancer; no supplement, no mineral, no roots from China. It is total BS at the stage and AGE you are at.
Maybe if you were born now and had the absolute healthiest lifestyle possible and the best possible non-mutable genes - and took all the supplements, tinctures, teas and pills holistic medicine has to offer MAYBE MAYBE MAYBE you might have some effect on your cancer.
But after a lifetime of 70+ years, exposed to carcinogens you are not even aware of and eating a diet that was probably less than optimal, you got what you got and now it’s time to allow many decades of sound medical research help you live a lot longer.
Your PSA, as pointed out, is far from the .2 necessary for treatment and even though your Decipher score is suggesting a more aggressive form of cancer, ADT is an incredibly powerful tool for preventing its spread, and side effects in most cases - especially at your age (sorry, but them’s the facts) are not too tough to deal with.
Of course, it’s always your choice and YOU will be the one who decides. I only caution against losing valuable time dicking around with unproven remedies; don’t be another Steve Jobs, a man who always thought he was the smartest guy in the room and died because he wasted over a year using unproven herbs, roots, etc. By the time he had surgery, it was too late. Best to you!
-
Like -
Helpful -
Hug
6 Reactions