Berberine didn't help me, the only thing that has helped me has been alpha lipoic acid and actually less works better. I only take 100 mg a day and a super b complex three times a week, and choline with inositol three times a week. I'm hypoglycemic AKA low blood sugar and berberine got me too shaky and faint, but it might be helpful for people that have high blood sugar and want to keep it from damaging their nerves which in turn will help with neuropathy.