Hello @newyorknill, I have not taken berberine for neuropathy but I do take a lot of other supplements. I have idiopathic small fiber peripheral neuropathy with only numbness and some tingling but no pain. I posted my neuropathy story in another discussion here - https://connect.mayoclinic.org/comment/310341/.

There are quite a few discussions and comments about berberine but I didn't see any others except this one in the neuropathy group. It might be helpful to scan through the comments and discussions to read what others have shared. Here's a link to that lists the discussions and comments on berberine - https://connect.mayoclinic.org/search/discussions/?search=berberine.

Not sure if you have seen this research on your question but thought I would share it with you.
"Does berberine help with neuropathy?
Diabetic neuropathy (DN) causes sensory dysfunction, such as numbness, tingling, or burning sensations. Traditional medication may not ease pain and discomfort, but natural remedies such as Berberine (BR) and vitamin E or Tocopherol (TOC) have therapeutic potential to reduce inflammation while improving nerve function."
-- Exploring the Therapeutic Potential of Berberine and Tocopherol in Managing Diabetic Neuropathy: A Comprehensive Approach towards Alleviating Chronic Neuropathic Pain:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10296327/
You might also want to check out the list of supplements that are included in the Foundation for Peripheral Neuropathy's complementary and alternative treatments document - https://www.foundationforpn.org/wp-content/uploads/2020/08/Complementary-and-Alternative-Treatments-Revised-2020-final.-1.pdf

Hoping you find some answers.