Hi. I just found your post, and I see it's dated from three years ago, so I'm not sure if you're still following replies.

I've had multi-focal LC since 2018. I was originally diagnosed in 2008 with a large NSCLC tumor, underwent chemo and radiation and was cancer free for ten years. Then in 2018 I began experiencing recurrent malignant lung nodules in both lungs, which we've been treating with radiation. I've had five of them so far and apparently I have "multiple" nodules that we're watching and that continue to grow and become solid. We've just found that one we radiated in 2018 has become malignant again (apparently the radiation wasn't effective enough). Because I've now been told by my radiologist that she's not willing to treat me with more radiation anymore (despite not experiencing any side effects), my options now are limited. I'll probably have to undergo wedge resection surgery.

I've been following a clinical trial at MD Anderson using the immunotherapy drug Keytruda for lung nodules (the IMPRINT trial), and was able to speak with the doctor in charge of the trial who gave me more information. He informed me that although the trial won't be over until 2025, they're seeing that Keytruda is reducing and even eliminating these nodules in many of the participants after only three treatments. This is probably the next route we're going to try, although I'm a little wary after reading how bad the side effects could be with Keytruda.

I'd like to know more about your progress so far. Multi-focal LC seems to be becoming more common.