I know you asked redroadtraveler, but I thought I would answer your questions by saying what my husband's recent experience with Pluvicto was. As he said, every man's experience is different, so keep that in mind as different people answer you. My husband had Pluvicto treatment at Mayo Rochester from January 2024 through August 2024. In September 2024 he had a Choline C-11 PET scan and lab work to determine how successful the treatment had been. (Dr. Kwon's protocol is to get a PSMA PET scan near the end of Pluvicto treatment and then a C-11 PET scan after treatment has concluded, because the scans look for different types of cancer cells.) The September C-11 PET showed the targeted metastases to be faded and likely destroyed by the Pluvicto, and also showed no new Choline-avid metastases. This was good news. However, my husband was disappointed that his PSA did not become undetectable as a result of the Pluvicto infusions. The nuclear medicine and urology teams both said he nonetheless had a very positive result of the treatment. The Kwon team has scheduled him for a PSMA PET and abdominal/pelvic MRI on January 6 to see if any new metastases have appeared by then as a result of cancer hiding in his body. As they always say, "we can't treat what we can't see." Keep in mind that other men who post here about their Pluvicto experiences may have had better or less good outcomes. There are no guarantees, but it is now standard of care for some men who are Stage 4 and have progressed on other treatments.