@hopeandhope - try one, give it a week and see how you feel. If that time doesn't work for you, try another and see how that goes. For me, bedtime made the most sense. I typically hit the bed between 10-10:30 so it became pretty routine for me to just inject before bed. Mornings were more difficult because I play pickleball a few times a week, and lift weights the other few days and sometimes the increased heart rate that I got with Tymlos got my heart really pumping when I was exercising. So, bedtime and a time to just relax, really helped. You'll figure out what's best for you. Rose