I agree with the study. I wasted almost 2 years on the Big 3, and didn't do anything for me. I have 2 lesions / cavities. After starting the Arikayce...so far, my last CT scan showed shrinkage of my cavity. In hindsight, I wish I started with the Arikayce from the beginning. I still question why they want me to continue with the antibiotics that did nothing for me, along with the Arikayce. But I am reluctantly following the protocol.