Under the STAMPEDE protocol the only patients who would take it until resistance are those with distant metastatic disease. Locally advanced or contained with high risk features only take it for 24 months.

I'm in a similar boat when it comes to heart issues, in fact, 2 MOs did not want me to start taking it because of the cardiotoxicity. I got screened by my cardiologist who gave me a solid thumbs up so I will hit the 2 year mark of taking abiraterone and Orgovyx in April, although I started taking Orgovyx 10 months before adding abi. The cardio put me on a beta blocker to buffer the effects of abi + prednisone.