@newengland transplant I read the part of the ARCH study you linked and it says Evenity "followed by alendronate" but does not specify timing. Does the FRAME study specify when alendronate should be started? I imagine there is leeway depending on CTX and other markers a month after Evenity is stopped.

ps That link discusses studies on cardiovascular risk which would help people who are scared of the black box warning. No calcification of blood vessels has been seen in studies so far and the link mentions that the difference between Evenity and alendronate results may have been because alendronate is slightly protective. It also mentions the FRAME study where there was no difference is CV risk between Evenity and placebo. The CV risk remains theoretical in other words.