Sue, I have a question, I too take Annoro but opted to take it in the evening because I couldn’t sleep at night because of accumulation of mucus. I take it around 7:30-8:00pm. I love the idea of taking it during the day so possibly no need to nebulize or rescue inhaler. Now we know can only do Annoro once every 24 hrs, so do you take anything in the evening? Or does your one dose of the Annoro last you the full 24hrs or close to it? When I first started it about 3 years ago it really lasted 12-16 hrs. But now only seems to last 8-10hrs maximum, any thoughts or advice? Your thoughts and advice are always appreciated. Thank-you.