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In praise of Orgovyx

Prostate Cancer | Last Active: Oct 17 2:02pm | Replies (39)

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@northoftheborder

That's interesting. Do you mean the PATCH trial?
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00100-8/abstract
I'm not sure it would make a difference for most of us (either way, participants still got gynomastia, hot flushes, etc and an elevated risk of heart disease), but as you mention, if taking estrogen instead of suppressing testosterone reduces the risk of liver damage, it could be useful for people showing concerning liver-related values in their bloodwork. Something else that it's worth keeping an eye on as this trial continues.

Key quote:

"Long-term data comparing tE2 patches with LHRHa show no evidence of a difference between treatments in cardiovascular mortality or morbidity. Oestrogens administered transdermally should be reconsidered for androgen suppression in the management of prostate cancer."

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Replies to "That's interesting. Do you mean the PATCH trial? https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00100-8/abstract I'm not sure it would make a..."

Thanks for bringing me the name of the trial, probably could’ve looked it up but this saves time. I remember so many of the tests and trial results, but it’s hard to remember the name of the exact trial when you’ve been on ADT for so long.