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Is a PSMA-PET scan of value if you have already started ADT treatment?

Prostate Cancer | Last Active: Oct 10 6:20pm | Replies (15)
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@florida11

Dr. Kwon's team at Mayo recently told me that 10-22% of men can have undetectable PSA's, while cancer continues to show up on a scan and potentially keep growing/spreading. So his team has patients do a lot more frequent PET scans that someone like my local oncologists would (which is one of the many reasons I fly to MN). This gives more options to radiate spots, start treatment earlier, etc. before things get worse.

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jeffmarc | @jeffmarc | Oct 10 11:59am

Even more on that topic

About 10% of men do not produce PSMA and don’t show anything on the PSMA PET test

In that case, they need to do an FDG PET test to see if they have any metastasis.

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northoftheborder | @northoftheborder | Oct 10 6:20pm

Thanks for sharing that.

I'm aware of this 2007 lit review concluding that some people still had prostate-cancer progression with PSA of 0.1–0.2. Have there been more recent studies showing people still progressing when their PSA is undetectable on the newer ultrasensitive PSA tests (e.g. < 0.01)?
https://pubmed.ncbi.nlm.nih.gov/17171704/

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