My personal opinion is ABSOLUTELY YES. I am not a doctor and I recommend the patient ask a doctor the detailed questions to understand the relationships between these two indicators. My understanding is while PSA and PSMA-Pet scan both can indicate cancer levels they use completely different mechanisms to detect cancer and that the newer PSMA based pet scans can detect much lower levels of cancer than previous pet scans. Most importantly the pet scan will tell you where cancer exists in your entire body. PSA is only an indicator for cancer in the prostate.

In my case prostate biopsy indicated it was unlikely my cancer had spread beyond the prostate but my care team scheduled a pet scan which would have detected if any cancer was in any of my lymph nodes or elsewhere in my body. Fortunately my scan showed the cancer was only in my prostate but if it had spread elsewhere I would have wanted to know.

I visited 6 doctors including urologists, oncologists, radiation and surgery specialists before I selected my doctor and treatment. The biggest lesson I learned was that while all of them were well intentioned their recommendations for types of tests is limited by their specialized knowledge and testing resources readily available. In the end I went to Mayo Phoenix because they gave me more options than all the other doctors combined.