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Just finished 1 yr of Evenity and will start prolia next if I don't negotiate a new plan with my endocrinologist. I am 76, just starting hrt again after many years without... estrogen, testosterone and progesterone.
I intend to talk with my endocrinologist about this possibility....one or two injections of prolia and then back to evenity or tymlos???? I have already had two years on forteo.
Replies to "Just finished 1 yr of Evenity and will start prolia next if I don't negotiate a..."
@gravity3 I'm one of those who has serious concerns about Prolia. Also I am not at all sure that Prolia being substituted for Fosamax makes sense. The general problem with long term Fosamax (longer than 3-5 years) is that bone remodeling is suppressed too much for too long a time period. Bones can become fragile despite keeping their density. Is it proven that switching to Prolia a more powerful suppressor of bone remodeling solves the problem of overlong suppression? I believe I've heard some discussion of whether alternating anabolics with bisphosphonates might help deal with the problem of overlong suppression. The anabolics would cause remodeling to resume and potentially improve bone quality and architecture which would perhaps undo some of the harm of overlong suppression of bone turnover.
This is all theoretical, and wishful thinking on my part as that is the direction I'm going in. I will point out in my defense that much of what has happened over the past 30 years with osteoporosis medications at least in terms of a long term solution is not based on solid evidence. For example they gave folks Fosamax for years and years and years. They only knew it was ok for 2-3 years. Did no one think then that maybe suppressing bone turnover forever might cause some problems? Similar thing with Prolia did it occur to no one that very strongly suppressing might not cause some problems when you stopped the suppression?
Anyway I think it is reasonable to take Fosamax again for a short period, 1 year say, especially when you are alternating it with an anabolic med.
I had Evenity for 1 year and have moved on to Prolia to help build more bone density. I will do 2-3 injections and then Reclast. I started BHRT almost a year ago at 71 years. My endocrinologist was against it and all new studies were pointing in the right direction. Look for video’s on YouTube by Dr. Doug Lucas. Hope that this helps with your decision going forward.
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@gravity3 Tymlos after Prolia might be risky in terms of rebound and various resources (McCormick, Leder) say it also isn't effective.
You or someone else shared a study on Evenity in that situation and it did seem to counter rebound and had was effective though effeciveness was reduced by prior Prolia.
Are you avoiding a bisphosphonate?