adult granulosa cell tumor. Abdominal and pelvic relapse confirmed.
I have body discomforts and feverish feeling, nothing severe, now having bit constipation, no abdominal pain
I missed a scanning between Oct 2023 and July 24. 3 months back visited surgeon for check up, said everything fine. Suggested pet scan to be free for next one year.
My initial treatment over in june 2021. No medications.initially my stage was III 2b. First surgery was unplanned hysterectomy. After that did Chemo,again laprotomy for CRS and hipec did. Later in March 2022 two small lesions reported in pelvic area and in Oct 2022, 2 lesions reported near liver, did biopsy but result was negative. Was under follow-up with CA 125 and ultra sound., till Oct 23 no changes noted. In April 2024 little hike in CA 125 noted (17.8)., was below 10 after treatment.
I used to go gym for the last 2 years, but intensive training started in feb24. Later I reduced 7 kg . I was 77 kg in Feb, now 70 kg. No abdominal pain while doing exercise. I used to feel very fresh and active after gym workout. Not felt unusual tiredness, now also I am physically active and fine.
CBC, blood sugar, TSH, liver function test, urea creatinine- everything normal.
Inhibin B shows elevated >1000.8, tested for the first time now.
My first issue was in 2012 with a cyst in left ovary, which was removed by laproscopy immediately
Doctors did CRS only. As it took more than 14 hours. removed all tumors and could do it perfectly.
Colon anastomosis near rectum has been done as they find one tumor nearer to that.
Now biopsy result. Recurrence confirmed. Suggested chemo 4 or 6 cycles based on inhibin B value after one month. Said to start on 21st day. cbc values shows variation.
Clinical Data : Known case of recurrent granulosa cell tumor
IHC Findings IMMUNOHISTOCHEMISTRY:
ER: Positive, 1+/2+ nuclear positivity in 30% tumor cells
PR: Positive, 2+/3+ nuclear positivity in 90% tumor cells
Ki67: 1015% activity.
Controls satisfactory.
Antibodies clones:
ER(Sp1 ROCHE), PR(IE2 ROCHE), Her2 Neu(4B5 ROCHE), (MIB1
Pathnsitu).
Welcome, @reenajosep. I moved your post to this existing discussion:
- Granulosa cell (GCT) ovarian cancer: Suspect recurrence, how to cope?
https://connect.mayoclinic.org/discussion/gct-cancer-slow-recurrence-suspicions/
I did this so you click the link to read previous posts and connect with other members living with granulos cell tumors, like @dovebeloved @cpl @imr @sophiaphilia and others.
Reena, have you started chemo yet? How are you doing?