My husband did the 12 rounds folfirinox, then a maintenance for 4 months without the oxy which allowed him to regain some weight and strength and have a little more life this summer. Unfortunately his CA19-9 numbers started climbing again and scans showed growth while on the maintenance. So he has once again started the full dosage. This time they are trying the cold therapy while getting the chemo... cold booties and mittens, plus spooning ice chips in his mouth for the last two hours of infusion. Reasoning is to stop the neuropathy from getting worse. He's only had two sessions of it, so unknown if that will help. Though he felt for the first time an uncomfortable spot in his throat so he is wondering about continuing with the ice chips.