A friend told me to ice my hands and feet while on Taxol. I met resistance from the infusion nurses, but the agreed to it. I have minimal to zero neuropathy, but another friend was not told that and after 5 treatments she was unable to walk and she was getting treatment at a Premier cancer institute. After people questioned me about it, I was told by the intake nurse that it had helped so many others who witnessed it and has helped so many people since. I don't understand why other facilities aren't telling people this. The boots and gloves are available from Amazon, so I changed them out every 15 minutes. I wish you all had known this ahead of time.