I just saw a Cardiologist the other day. I told her about my Bronchiectasis and chronic Pseudomonas infection and that it might be difficult figuring out lungs vs heart. For me the infection greatly affects my breathing but along with that is increased heart rate. She very much agreed that diagnosing a heart issue when someone has lung disease can be more difficult. She was not even able to listen to my heart. She said she could not hear it since my lungs were so loud! She has ordered an Eco. Anyway to your question about SOB and tiredness the answer is YES Pseudomonas will most definitely cause that as will Bronchiectasis in general. But of course so can CHF. Trying to sort out which is causing more issue may be difficult. Did you say if your husband is doing airway clearance with saline and a flutter device?