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Bone turnover markers (CTX and P1NP): do you have a baseline?

Osteoporosis & Bone Health | Last Active: Oct 5 5:35pm | Replies (183)
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@balake

Question:

60 year old Male. Pretty Athletic. Delayed back surgery due to Osteoperosis.
My CBeta-CrossLaps (B-CTx), S is: 1105
My Procollagen I Intact N-Terminal, S is: 106
Makes my ratio around 10:1
Do these numbers seem oddly high, or is this relatively common?
Responses from two doctors" one shrugged and said it didn't mean much, the other seemed shocked and suggested drugs.

Also, should I be fasting and taking test in the mornings?

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Replies to "Question: 60 year old Male. Pretty Athletic. Delayed back surgery due to Osteoperosis. My CBeta-CrossLaps (B-CTx),..."
nme1985 | @nme1985 | Oct 5 6:49am

Take the tests in the morning after fasting. 1100 is on the high side, but I am not sure about male numbers. If you direct message @mayblin she seems pretty knowledgeable. I would get an opinion from an integrative medicine specialist. Dr Bazzan in Philadelphia is excellent. Good luck.

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mayblin | @mayblin | Oct 5 9:09am

Hi @balake I agree with @gently, if this is your baseline bone marker readings, the CTX looks high. For males around 60yo, the upper boundary of reference range for CTX seems to be in the 700s (although an Europian assay renders 1000-1100 CTX reading for upper reference range) - it could vary somewhat with different assays and maybe among different ethnicity. Your P1Np reading is good, most likely due to the coupling effect. Unless you had a recent fracture and/or immobilization which could increase CTX and P1NP, it's worth looking into the cause(s).

Have you taken any osteodrug(s)?

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