How long did your doc have you on Tymlos?

@susyt did you have your bone turnover markers (CTX and P1NP) tested before you started Tymlos as a baseline? If so, do you mind sharing the numbers?

As you probably know, CTX is a marker for bone resorption (breakdown), and p1np for bone building. They are useful in monitoring treatment progress for an anabolic such as Tymlos, with certain limitations. If your baseline P1Np is within reference range for postmenopausal women, then your two readings of 191 and 220 were very impressive - an indication that Tymlos is working great! If you feel great at 50mcg Tymlos currently, you could gradually increase the dose to reach a maximum dose thats tolerable to you. I suspect the bone density increase with Tymlos is dose dependent and 80mcg is the dose thats marketed to achieve the desired end results. Moreover, the longer you stay on Tymlos (to a max of 18-24 mo), the more bone you will build. This is backed by clinical studies.

Wish you the best!

I just started on Tymlos. I am having trouble trying to give myself a lower dose. Today, when I pushed the button to inject the medication, the dial immediately went back to zero. I assumed I didn’t get any medication so I tried twice more. Each time, the dial reverted to zero as I was pushing on the button. To top things off, a needle broke, leaving a tiny length inside. I injected myself a total of three times but don’t know if I got a little medication or not. Has anyone else had a similar issue?

I’m hoping @windyshores will chime in but after you inject the dial automatically resets to zero. Were you going by clicks or did you turn the dial all the way?

I went by clicks. I was trying to do two clicks.

@freuab1 you turn the pen and feel the clicks. Then inject. The pen then goes back to zero as @bluebonnet232 said. We could help more if we understood whether you are able to feel the clicks.

Having a piece of the needle stuck inside your skin sounds like a need for a quick MD visit. How did that happen? Did you do three injections with the same needle? That can cause problems because the needle is less lubricated I believe.

If you injected three times as you described, maybe you got three times what you intended!

Yes, I used the same needle. I didn’t realize it could create a problem. So much I don’t know! I turned the pen before I inserted the needle. I heard the clicks. I think I felt them. But it seemed to me that as soon as I started to push in, the dial went back to zero. Maybe because it was such a small quantity? I pulled the broken off needle out with tweezers.

I did feel tired and a bit sick to my stomach so I must have gotten some.

The pen goes back to zero after you inject. Looks like you can tolerate a bigger dose! I recommend, based on experience, not reusing a needle!

Thank you, windyshores. I won’t do that again. I appreciate being able to come here with questions.

#fresian1 I should have said that a nurse at your MD office could be helpful and actually observe what you are doing. My response was a guess!