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Prostate Cancer, Stage 4, spine & pelvis, Eligard, now abiraterone

Posted by albert785 @albert785, Sep 13 8:06pm

Hi, as the topic says, I am Stage 4, they started me on Elegard and less than 3 months later they want me to start taking abiraterone (Zytiga) along with prednisme.
Has anyone run into this situation that can tell me their experience?
Thank you very much.

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ddl | @ddl | Oct 3 7:46am
In reply to @jeffmarc "Most people don’t have problems with liver enzymes. I was on abiraterone for 2 1/2 years..." + (show)
@jeffmarc

Most people don’t have problems with liver enzymes. I was on abiraterone for 2 1/2 years and never had an issue, but they checked it every month.

I know some people have reduced it to three pills and even two pills and still had good results. For me, I reduced it to three pills and in 18 days, my PSA went from .2 to 1. Not very successful.

If you try to reduce it, make sure to get a PSA test real soon. With a Gleason nine your body may not like less than four pills.

After Abiraterone, when your PSA rises, you can try Darolutamide, it doesn’t affect the liver as much, normally, and the side effects are minimal for most people.

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Another thing you might research: there have been studies that show that 250 mgs of Abiraterone taken with a high fat breakfast results in the same blood absorption as 1,000 mgs taken after fasting.

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1 reply
jeffmarc | @jeffmarc | Oct 3 9:20am
In reply to @sicernon3 "Thanks for your comments. Yes, I have had to adjust my dosage to 3 abiraterone per..." + (show)
@sicernon3

Thanks for your comments.
Yes, I have had to adjust my dosage to 3 abiraterone per day because of liver enzyme issues. However, my PSA has remained at 0.0 for the last 4 blood tests. Hopefully we hold that pattern. Although I was Gleason 9, it was localized and the PET scan showed no metastasis. I began with 30 days of photon radiation

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Wish you the best. Since 3 Zytiga are working for you it sounds like you are in a good place. Your PSA remaining undetectable is really good news and with the clear PET scan you may have a long remission.

I know other Gleason 9 people who were able to stay clear for a long time.

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1 reply
jeffmarc | @jeffmarc | Oct 3 10:34am
In reply to @ddl "Another thing you might research: there have been studies that show that 250 mgs of Abiraterone..." + (show)
@ddl

Another thing you might research: there have been studies that show that 250 mgs of Abiraterone taken with a high fat breakfast results in the same blood absorption as 1,000 mgs taken after fasting.

Jump to this post

A few people in the Ancan.org weekly advanced prostate cancer chat I attend are doing this and it works quite successfully. You have to eat the right food, a low-fat breakfast.

Just as effective as four pills on an empty stomach.

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Sicetnon3 | @sicernon3 | Oct 5 9:35am
In reply to @jeffmarc "Wish you the best. Since 3 Zytiga are working for you it sounds like you are..." + (show)
@jeffmarc

Wish you the best. Since 3 Zytiga are working for you it sounds like you are in a good place. Your PSA remaining undetectable is really good news and with the clear PET scan you may have a long remission.

I know other Gleason 9 people who were able to stay clear for a long time.

Jump to this post

Yes, I am grateful for the place I am.

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