@19kcm56 I watched the video and there was a difference in the middle of the graph (in the middle of 10 years) where the 1 mg dose line was much lower than the 5mg line.

I have had two low dose infusions (1 mg each) due to kidneys and afib. I would certainly like to believe that is enough but have strong doubts.

I do believe the 5mg dose was chosen because it covers everyone (like the Evenity dose)- even though it might overdo it for us lightweights.

Reclast can be given at a low dose fairly easily. But that means, at this point, with the protocols in place, that doctors want that low dose given more frequently- 1 mg 4-5 times/year for instance. This would overwhelm the medical system, the cancer infusion centers and the insurance system.

I am not saying there should not be lower doses. But medical appropriateness is clearly not the top priority. Nuance in dosing is expensive and administratively difficult, unfortunately.

Personally I am not sure the lower dose lessens side effects either!