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Weaning off of prednisone & pain management

Polymyalgia Rheumatica (PMR) | Last Active: Oct 25 10:23am | Replies (156)

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@dadcue

I don't have any experience with Kevzara. I have taken Actemra for PMR for a long time. Kevzara and Actemra are similar and worked basically the same way. Both Kevzara and Actemra are both IL-6 inhibitors.

I can tell you that it took me about 6 months to taper from 10 mg down to 3 mg of Prednisone. I had to stay on 3 mg of Prednisone for another 6 months because of adrenal insufficiency. I was referred to an endocrinologist who I still see because of side effects from long term Prednisone use. My long term Prednisone use was 12 years.

The duration of prednisone use impacts how soon you may be able to taper off Prednisone. This is due to adrenal insufficiency and also whether or not PMR is in remission. If your adrenals don't recover very soon, you may have a need to continue replacing cortisol with Prednisone.

When my cortisol level improved, my endocrinologist said I could stop taking Prednisone. She said no tapering was necessary from 3 mg to zero as long as my cortisol level was adequate.

I did a fast taper from 3 mg to zero in a week or two. I understand your reluctance to taper too quickly because doing a "slow taper" was all I was ever told to do. However, I was able to discontinue Prednisone quickly once my cortisol level improved and PMR was in remission. Both things need to happen!

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Replies to "I don't have any experience with Kevzara. I have taken Actemra for PMR for a long..."

Thank you for your response. I have no idea how my adrenal glands are doing. Hopefully all goes well for me. I have been on prednisone since February. So happy for you that you're off prednisone.