1. < Osteoporosis & Bone Health

Evenity and Bone Markers

Posted by marymj7 @marymj7, Sep 10 2:56pm

Can testing bone markers part way through Evenity treatment indicate whether or not it's working? My baseline numbers are what I believe Dr. McCormack would label as optimal, yet I have severe osteoporosis. CTX in the 200s. P1NP 39. I will have bone markers tested soon ahead of my fourth set of Evenity injections. Has anyone had bone markers done while on Evenity?

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Michael Lavacot | @michaellavacot | Oct 1 5:47pm
In reply to @kristie2 "Michael , Why may I ask are you not moving on from Prolia to Reclast ?" + (show)
@kristie2

Michael ,
Why may I ask are you not moving on from Prolia to Reclast ?

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Hi @kristie2 , I likely will move from Prolia to Reclast once I achieve my targeted T-score on Prolia. Knowing that I will have a rebound of about 1/2 of a T-score when I stop Prolia (after many years), my target for spine will be -1.5 to -1.0 before I switch.

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kristie2 | @kristie2 | Oct 1 9:54pm
In reply to @michaellavacot "Hi @kristie2 , I likely will move from Prolia to Reclast once I achieve my targeted..." + (show)
@michaellavacot

Hi @kristie2 , I likely will move from Prolia to Reclast once I achieve my targeted T-score on Prolia. Knowing that I will have a rebound of about 1/2 of a T-score when I stop Prolia (after many years), my target for spine will be -1.5 to -1.0 before I switch.

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That’s a great goal !

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marymj7 | @marymj7 | Oct 6 12:06pm
In reply to @michaellavacot "Attached are the results from another Evenity (Romosozumab) trial showing the CTX and P1NP results over..." + (show)
@michaellavacot

Attached are the results from another Evenity (Romosozumab) trial showing the CTX and P1NP results over time. I have circled the three month period. From the bars shown for each time period, you do fall within expected results. I think you just need to ride out the year and see how you do.

As for CTX falling too far, I don't think you have to worry about that. To put the numbers into perspective, I'm on Prolia and my CTX is 37. Even with Prolia, ONJ risk is very low.

My two cents, stay the course on Evenity! Good luck.

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Now I remember that you and I corresponded before I began Evenity. I, too, have high urine calcium (apparently idiopathic). If i recall, you didn’t have much gain on Evenity?

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Michael Lavacot | @michaellavacot | Oct 6 2:20pm
In reply to @marymj7 "Now I remember that you and I corresponded before I began Evenity. I, too, have high..." + (show)
@marymj7

Now I remember that you and I corresponded before I began Evenity. I, too, have high urine calcium (apparently idiopathic). If i recall, you didn’t have much gain on Evenity?

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Well, that's a long story. As it turns out, I actually had pretty good response on Evenity. They messed up my first DXA scan and scanned L2-L5 instead of L1-L4. All said, I gained about 11% BMD in the spine and about 5% in the hip. Since I lose both calcium and phosphorus in my urine, I supplement both to try to keep serum levels where they need to be. I'm still working on the root cause and it seems to be a kidney thing. My 1,25(OH)2 vitamin D is also too high as well as my FGF23. It's pretty complicated. 🙂

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