My research has found that ALA with B1, specifically, Benfotiamine (more bio-available) has greater efficacy. Anecdotally, it has improved my Peripheral Neuropathy, along with Magnesium, and D. I had the condition, and it was made significantly worse by taking a fluoroquinolone antibiotic, known as Ciprofloxacin (there are many), known for it's eight Black Box Warnings from the FDA, by everyone except the medical community. To make matters worse, the same medical group gave me five injections of Prednisolone Steroids concurrently. I'll spare you my "tale of woe," suffice it to say, it's extensive.