A colleague did have similar symptoms being treated with antibiotics for BPH and potential prostate stones, after a MRI and biopsy were negative. After the PSA did not decrease over a 6-month time period, he was subsequently scanned using better MRI (3T multi-parameter MRI - mpMRI) which detected a potential small tumor (I don't know tumor size) in the prostate. After a MRI guided biopsy confirmed a small tumor, he is now awaiting Decifer test results to decide on AS or treatment options. Until the results of the 3T mpMRI, my understanding is that his urologist believed the rising PSA was due to a stubborn infection in the prostate and had other patients with similar symptoms (rising PSA, no detected cancer).