Hi, my hubby has been on Tagrisso for EGFR protein, left lung that had one lobe surgically removed and unsure of a couple of lobes showing possibilities, so reason for the study of Tagrisso for 3 years which will be up in 15 days, then off the Tagrisso due to it no longer being effective?? No contrast ct scans over the 3 years showed any recurrence of cancer, so perhaps that is the reason for the 3 year term. Tagrisso was taken at 1 pm daily (by choice of convenience), and other than lack of energy, and having to nap once a day after lunch due to tiredness I guess there was no real side effects. At the beginning I felt his skin was extremely dry and his feet could crack and if not drinking his 8 glasses of water a day, rashes could form. Persistently used glazel base cream which has no scent to it and it seemed to do the job. Has a good appetite with smaller portions I am seeing and if not enough food consumed he looses weight real fast. Intake of calories has been so important to keep up his weight as he lost 10 lbs. when lobe removed and has at least put 5 lbs. back on. Don't believe there is any time of day that you can't take Tagrisso, what is convenient and easy for you to remember, just be persistent in following that same time everyday.