I'm sorry to hear of the adverse events you experienced with the up titration of you oxaliplatin dosage. While, I'm not an oncologist I am trained in clinical pathology & laboratory medicine. Given the symptoms you've described, it would appear that you suffered an acute/chronic hypersensitivity reaction to your last up-titration of you oxaliplatin dosage.

This may occur within hours of the infusion and is characterized by an autoimmune-like or idiosyncratic immune-mediated hemolytic anemia and/or thrombocytopenia due to repeated oxaliplatin infusions. Patients may also experience episodes of hypotension and other cardiac symptoms that require suppotive care and rarely, episodes of chronic productive coughing. If you are thrombocytopenic and have reduced clotting capacity you may also experience episodes of hemoptysis (coughing up bloody sputum).

I've had a similar experiences requiring hospitalization while undergoing FOLFOX chemo for stage 4 ESCC. I assume that your oncologist and the other members of your treatment team were/are actively monitoring your CBCs for evidence of neutropenia, anemia and thrombocytopenia. As I'm sure you are aware, neutopenia (low neutophils) can markedly lower you resistance to infections and thrombocytopenia (low platelets) can render you more susceptible to bleeding. Higher doses of oxplatin may also be associated with increased cough. These oxaliplatin related side effects may explain your episode of hypotension and pulmonary issues of cough and hemoptysis. After the supportive care they've provided render you stable with regard to your blood pressure, neutrophil counts and restoration of exceptable platelet levels, they may switch you to a FOLFIRI chemo regimen.

In my experience, FOFIRI, a second line therapy for EC, is usually more tolerable than FOLFOX as regards development/worsening of peripheral neuropathy, neutropenia and thrombocytopenia. Thus far, it seems to be as effective as FOLFOX with respect to the maintenence of my sustained good clinical response and disease control.

I wish you well in your journey with our unwelcome fellow traveler.