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This worries me that my ctx will get too low. It was only 234 at baseline with no meds. P1NP was 39 at baseline no meds. I have had 3 doses: 7/5, 8/5, 9/6. Had labs done 9/23. CTX 193. P1NP 43. I will not have any more doses, but the drug will remain active for another couple of months due to long half life. Do you think my ctx will keep falling? Scares me, especially about ONJ risk
Replies to "This worries me that my ctx will get too low. It was only 234 at baseline..."
Attached are the results from another Evenity (Romosozumab) trial showing the CTX and P1NP results over time. I have circled the three month period. From the bars shown for each time period, you do fall within expected results. I think you just need to ride out the year and see how you do.
As for CTX falling too far, I don't think you have to worry about that. To put the numbers into perspective, I'm on Prolia and my CTX is 37. Even with Prolia, ONJ risk is very low.
My two cents, stay the course on Evenity! Good luck.
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@marymj7 you might want to watch Dr. Ben Leder's video on YouTube entitled "Combining and Sequential Approaches to Osteoporosis." There is a chart on there that shows what happens to CTX on Evenity. From what I could gather, it is a pretty mild anti-resorptive. My doc says they don't really understand how it works. After a couple of shots my CTX was lower than yours and I wasn't worried ! I waited two months to do Reclast after 4 Evenity's at my MD's suggestion.