I have had MAC/MAI for almost two years now and under the care of Mayo Jacksonville as well as an ID Doc where I live. I have had bronchiectasis for a number of years. Last February I stared the big 5 and the side effects were so bad I could only last until April. I lost 20 pounds (and I am thin to start with), had constant vomiting, no energy, slept 12 hours a day, etc etc. I have now been off all antibiotics since then and am only doing air clearance therapy including nebulizer and percussion vest twice a day. Having trouble putting the weight back on, but have my energy and appetite back and trying to get as much exercise as my 86 year old body can get. The cough is relatively constant but I am able to bring up lots of mucous on a regular basis and that is a good thing. I rather live my life this way than feeling as bad as I did while taking antibiotics. There may be a better way but haven't found it yet. Will visit with all Docs again this fall and see if they recommend anything new. Anxiously awaiting the release of the new bronchiectasis medicine which is currently awaiting final approval tab the FDA. This probably won't help anyone but that is my status. PC